Hydrolyzed Hyaluronic Acid Powder (Pure Acid Form, Non-Salt)
Hydrolyzed Hyaluronic Acid Powder (Non-Salt / Pure Acid Form) is a premium, cosmetic-grade raw material engineered for advanced skincare formulations. Unlike conventional sodium hyaluronate, this pure acid-form ingredient remains un-salted, preserving its natural active integrity and maximum biocompatibility. Thanks to its ultra-low molecular weight, Hydrolyzed Hyaluronic Acid Powder bypasses surface barriers to deliver deep dermal hydration, structural repair, and exceptional formula stability in serums, creams, and aqueous solutions. As a high-purity B2B ingredient, this non-salt hyaluronic acid raw material contains zero additive fillers—making it the preferred choice for cosmetic chemists, formulators, and clean-beauty brands seeking pure, non-irritating, and deeply penetrating anti-aging ingredients.
Item | Specification |
|---|---|
Product Name | Hyaluronic Acid Powder |
INCI Name | Hydrolyzed Hyaluronic Acid |
Form | Acid Form (Non-Salt Form / Non-Sodium Hyaluronate) |
Appearance | White or off-white fine powder |
Purity | ≥95% |
Molecular Weight | Customizable (1000Da – 50kDa) |
PH | 2.5-3.5 |
Heavy Metals | ≤20ppm |
Bacterial Count | ≤100Cfu/g |
Pure Acid-Form Hydrolyzed Hyaluronic Acid Overview
Our Hyaluronic Acid Powder is strictly manufactured in acid form, completely different from the common sodium hyaluronate (salt form) on the market. We retain the original molecular structure of hyaluronic acid, ensuring higher biological activity, better stability, and no ion interference – perfect for your strict formulation needs. Unlike regular salt-form HA (sodium hyaluronate), our product is 100% acid-form hyaluronic acid, with no sodium ion residues, no chemical modification, and retains the natural biological activity of HA. Made via advanced bio-fermentation and purification technology, purity ≥95%, free of heavy metals (≤10ppm), endotoxins (≤0.05EU/mg for medical grade), and any additives – meets international quality standards for cosmetics, pharmaceuticals, and health care.
Princeton Powder is a leading supplier of hyaluronic acid powder. HA powder in Acid form not salt form, is available in 1000Da to 50 kDa, tailored to your specific application needs (cosmetics, medical, oral care, etc.).
Low PH Hydrolyzed Hyaluronic Acid Technical Specifications
| Property | Specification |
|---|---|
| Product Name | Hyaluronic Acid Powder — Free Acid Form (Low pH) |
| INCI Name | Hyaluronic Acid |
| CAS Number | 9004-61-9 |
| Chemical Form | Free Acid (protonated -COOH) — NOT sodium salt. Convertible to NaHA via NaOH neutralization. |
| Key Advantage | Acidic HA form — native pH 2.0-3.5 compatible with AHA/BHA/VC formulations. Reactive -COOH for derivatization. Convertible to NaHA on-demand. Low MW <50 kDa for epidermal penetration. |
| Molecular Weight | <50 kDa (GPC-MALLS — low-to-super-low range for deep penetration) |
| Appearance | White to off-white powder; hygroscopic |
| Purity (HPLC-UV 205 nm) | ≥99.0% |
| pH (0.1% w/v Solution, 25°C) — Critical Quality Attribute | 2.0 – 3.5 (confirms free acid form — protonated -COOH groups) |
| pKa (D-Glucuronic Acid Carboxyl) | ~3.0 – 4.0 (typical for HA uronic acid — explains acidic behavior) |
| Glucuronic Acid Content | ≥44.0% (carbazole method — higher than NaHA due to no sodium content) |
| Sodium Content | 0% (free acid — no sodium; distinguishes from NaHA ~5-6% Na) |
| Solution Conductivity (0.1% w/v) | Low (few free ions — protonated -COOH does not dissociate significantly at pH <3.5) |
| Viscosity Building | Low to moderate; pH-dependent (increases upon neutralization as -COO⁻ enables chain expansion) |
| Solubility | Freely soluble in water (slower hydration at low pH; gentle stirring 15-30 min at 25°C or 5-10 min at 40°C) |
| Loss on Drying | ≤10.0% (105°C, 2h) |
| Protein Content | ≤0.1% |
| Heavy Metals (Total) | ≤10 ppm |
Pure Acid-Form Hyaluronic Acid Applications
Our acid-form hyaluronic acid powder is the ideal raw material for:
– High-end skin care products (serums, creams, masks, eye care)
– Medical aesthetic materials (dermal fillers, medical dressings, wound care products)
– Pharmaceutical formulations (eye drops, joint injections, oral medications)
– Premium health supplements (oral tablets, capsules, functional drinks)
– Hair care products (scalp serums, hair masks, anti-hair loss products)
Hyaluronic Acid (HA) vs Sodium Hyaluronate (NaHA)
Many formulators use the hyaluronic Acid and sodium hyaluronate interchangeably — but they are chemically distinct materials with different pH, sodium content, and formulation behavior. This table provides a side-by-side comparison to help select the right form for your product.
| Property | Hyaluronic Acid (HA) — Free Acid | Sodium Hyaluronate (NaHA) — Sodium Salt |
|---|---|---|
| Chemical Name | Hyaluronic Acid (protonated form) | Sodium Hyaluronate (sodium salt) |
| INCI Name | Hyaluronic Acid | Sodium Hyaluronate |
| CAS Number | 9004-61-9 | 9067-32-7 |
| Carboxyl Group State | -COOH (protonated, uncharged) | -COO⁻Na⁺ (deprotonated, sodium salt) |
| pH (0.1% aq. solution) | 2.0 – 3.5 (acidic) | 5.0 – 7.0 (near-neutral) |
| Sodium Content | 0% (no sodium) | ~5-6% sodium by weight |
| Viscosity Building | Low-moderate; pH-dependent (increases upon neutralization) | High; forms viscous gels readily |
| Acid Active Compatibility | Native — no pH drift in AHA/BHA/VC formulas | May buffer acidic formulations toward neutral |
| Chemical Derivatization | Ideal — reactive -COOH groups | Requires protonation step first |
| Skin Penetration (MW-dependent) | Enhanced under acidic pH conditions | Standard; pH-neutral penetration profile |
| Formulation Target pH | 3.0 – 5.5 (or neutralized to higher) | 5.0 – 7.0 |
| Typical Usage Rate | 0.05 – 0.5% | 0.05 – 1.0% |
| Best For | Acidic serums, peels, AHA/BHA/VC, derivatization, acid-preserved systems | General moisturizers, gelled serums, sheet masks, neutral cosmetics |
Frequently Asked Questions (FAQ)
Q: What is the difference between your acid-form hyaluronic acid and the common salt-form (sodium hyaluronate) on the market?
- A: Our product is 100% pure acid-form hyaluronic acid, without sodium ion residues or chemical salt conversion. It retains the original molecular structure and higher biological activity, while salt-form HA (sodium hyaluronate) has a sodium salt structure, which may have ion interference and lower stability in strict formulations.
Q: Can I customize the molecular weight of the acid-form hyaluronic acid powder?
- A: Yes, we offer customizable molecular weight ranging from 1000Da to 50kDa, which can be tailored to your specific application needs (e.g., low molecular weight for skin absorption, medium molecular weight for medical dressings).
Q: What is the pH value of this acid-form HA powder, and will it affect my formulation?
- A: The pH value of our acid-form hyaluronic acid powder is 2.5-3.5. It is slightly acidic, which is consistent with the natural pH of human skin and most cosmetic/pharmaceutical formulations. It can be easily adjusted to match your formulation’s pH requirements without affecting product performance.
Q: Do you provide a Certificate of Analysis (COA) for each batch?
- A: Yes, every batch of our acid-form hyaluronic acid powder comes with a complete COA, which includes detailed test results such as purity, molecular weight, heavy metals, and bacterial count, ensuring product quality and transparency.
Q: How should I store the acid-form hyaluronic acid powder to maintain its stability?
- A: It is recommended to store the product in a cool, dry, and well-ventilated environment, away from direct sunlight, high temperature, and moisture. Sealed storage can effectively prevent degradation and extend the shelf life (usually 24 months under proper storage conditions).
Q: Is this product suitable for oral health supplements?
- A: Yes, our acid-form hyaluronic acid powder meets international food-grade and pharmaceutical standards, with high purity and no harmful residues. It is widely used as a raw material for premium oral health supplements, such as tablets and capsules.