Sodium Acetylated Hyaluronate (AcHA)
Sodium Acetylated Hyaluronate (AcHA) is a modified derivative of hyaluronic acid through acetylation, enhancing its moisturizing, anti-inflammatory, and skin barrier-strengthening abilities. It typically appears as a white or off-white powder, easily soluble in water, forming a transparent or slightly cloudy gel-like substance. Its molecular structure features acetylation of some hydroxyl groups, increasing hydrophobicity and skin affinity, while also improving enzymatic stability. AcHA usually has a purity of 98% or higher, ensuring safety and stability in cosmetic and pharmaceutical products. Due to its long-lasting hydration and repair properties, it is widely used in premium skincare and wound healing products. Its high purity and excellent biocompatibility make it an important ingredient in skincare formulations.
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CAS Number: 158254-23-0
Purity: 95% min
Synonyms: AcHA, Acetylated HA, Sodium Acetylated Hyaluronate
Particle Sizes: less than 60 mesh
Appearance: White Color
Description of Sodium Acetylated Hyaluronate (AcHA)
Sodium Acetylated Hyaluronate (AcHA) is a derivative of sodium hyaluronate (hyaluronic acid) with enhanced properties due to the acetylation of some hydroxyl groups on the hyaluronic acid molecule. AcHA combines the benefits of sodium hyaluronate with improved moisturizing, anti-inflammatory, and skin barrier-enhancing properties.
Chemical Composition of Sodium Acetylated Hyaluronate (AcHA)
| Items | Specification |
|---|---|
| Appearance | Powder |
| INCI name | Sodium acetylated hyaluronate AcHA |
| Recommended dosage | 0.01%-0.1% |
| Usage | soluble in water |
| Functions | Cosmetic application |
| pH | 5.0-8.0 |
| Molecular Formula | (C14+2xH20+2xNO11+xNa)n, x-Degree of acetylation |
| Degree of acetylation | 2.85-3.90 |
| Heavy metals | ≤ 20ppm |
| Arsenic | ≤ 2ppm |
| Bacteria count | ≤ 100cfu/g |
| Escherichia coli | Negative |
| Staphylococcus aureus | Negative |
| Pseudomonas aeruginosa | Negative |
| Storage | Lightproof, ordinary temperature, and sealed container |
| Validity | Two years |
Application of Sodium Acetylated Hyaluronate (AcHA)
- Skincare: Found in moisturizers, anti-aging creams, serums, and eye care products.
- Wound Healing: AcHA’s regenerative properties support wound healing and tissue repair.
- Haircare: Helps hydrate and protect the scalp and hair fibers.
Sodium Acetylated Hyaluronate (AcHA) Reference
Acetylated Hyaluronic Acid: Enhanced Bioavailability and Biological Studies
- Hyaluronic acid (HA), a macropolysaccharidic component of the extracellular matrix, is common to most species and it is found in many sites of the human body, including skin and soft tissue. Not only does HA play a variety of roles in physiologic and in pathologic events, but it also has been extensively employed in cosmetic and skin-care products as drug delivery agent or for several biomedical applications. The most important limitations of HA are due to its short half-life and quick degradation in vivo and its consequently poor bioavailability. In the aim to overcome these difficulties, HA is generally subjected to several chemical changes. In this paper we obtained an acetylated form of HA with increased bioavailability with respect to the HA free form. Furthermore, an improved radical scavenging and anti-inflammatory activity has been evidenced, respectively, on ABTS radical cation and murine monocyte/macrophage cell lines.